About the Webinar
In this webinar, Dr. Elphège Nora explores how cohesin-mediated loop extrusion shapes chromosome folding and how the dosage of specific cohesin cofactors tunes genome architecture while also creating vulnerability to genetic disruption. He will discuss how changes in extrusion rate affect chromatin organization, transcriptional control, and differentiation, with a focus on pluripotent stem cell systems and the mechanistic interpretation of Hi-C measurements through perturbation and biophysical modeling.
Key Takeaways:
- How cohesin and its cofactors regulate loop extrusion, and how their disruption changes distinct features of Hi-C measurements and chromosome folding behavior.
- How to move beyond Hi-C contact maps by extracting multiple complementary readouts of chromosome biology from the same experiment.
- How biophysical modeling can be used to interpret Hi-C data mechanistically and clarify the roles of architectural proteins in genome folding.
- Why dosage sensitivity, haploinsufficiency, and genetic imbalance in specific cohesin cofactors can offset one another in controlling chromatin architecture and transcription.
Publication
Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption – Rini Shah et al.
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Meet the Speakers
Elphège Nora, PhD
University of California, San FranciscoElphège Nora is a group leader at the University of California, San Francisco. His team studies the fundamental molecular mechanisms of chromosome folding and how these mechanisms relate to transcriptional control during the differentiation of pluripotent stem cells
Blake Skrable
Arima GenomicsBlake currently is an Associate Scientist at Arima Genomics executing various Hi-C-related studies and curating 3D genomic profiles. He received a Master's in Molecular biology from UCSD by studying RNA and ribonucleoprotein quality control pathways.